Histamine H4 receptor Research

Cost Action BMO806
Histamine H4 receptor Research
HARR4-Eu COST

WG3 - Pharmacological properties of new histaminergic compounds targeting the H4R

Ireland

Leader

Dr. Astrid Sasse

Dr. rer. nat. Astrid Sasse
Assistant Professor of Pharmaceutical Chemistry

School of Pharmacy and Pharmaceutical Sciences
Panoz Institute
Trinity College Dublin
East End 4/5,
Dublin 2, Ireland

+353-1-896 2797
sassea@tcd.ie
Web page

Italy

Co-Leader

Prof. Gabriella Coruzzi

Prof. Gabriella Coruzzi

Department of Human Anatomy,
Pharmacology & Forensic Medicine,
Section of Pharmacology,
via Volturno 39,
43100 Parma, ITALY

+39 0521 903857

gabriella.coruzzi@unipr.it

Web page

Evaluation of the pharmacological and physicochemical properties of new selective H4R ligands using data derived from SAR and dose-response relationships and preclinical investigations.
Consideration of modern tools such as SBVS and fragment based design for drug evelopment.
Consideration at the early stage absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of the new compounds, drug-likeness and drug ability.
Design of novel H4R ligands with additional properties concerning imaging (e.g. PET/SPECT ligands, fluorescence ligands) or pharmacological profiling (e.g. COX inhibition, immune modulation).

Contact info:Paul Chazot | Abdel Ennaceur
Webmaster: A Ennaceur
copyright: Histamine Research: Cost Action BM0806
updated: October 15th, 2011