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Training School on Histamine Bioinformatics

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Junior Research Fellowship Scheme, Durham, UK

Belfast Joint EHRS/COST Conference 2012

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Management Committee members, London (UK) - 17.12.2009

• to create a formal network of European experts with the goal to foster a multidisciplinary approach to H4R research


• to focus on the current state of play pertaining to the basic understanding & the huge therapeutic potential of this important new drug target


• to overcome H4R research fragmentation by enhancing communication, facilitating collaborations & building up strong links between academia, research & industry


• to broaden interdisciplinary training & mobility of young European scientists


• to promote H4R translational research & to attract industrial partners interested in the commercial exploitation of the results


• to set the standards & to develop a forum for free exchange of ideas & data leading to a template for best practice


• to increase the awareness of the general public & to disseminate the information on H4R to clinicians, medicines policy makers & health authorities

Working Group 1:
Methodological approaches for H₄R systems investigation

• Assessment & validation of methodologies targeting H4R distribution & characterization (in vivo, in vitro, in situ, in silico, molecular, cellular, genomic, transcriptomic studies)
• Development of assays to identify qualitative & quantitative modifications of H4R expression & distribution in disease states
• Determination of the optimal experimental conditions for the investigation of the mechanisms associated with H R functions & interactions in a range of cells & tissues

Working Group 2:
(Patho)physiological importance of H₄R systems

• Identification of H4R isoforms & elucidation of the molecular structure
• Integration & critical evaluation of data, derived mainly from basic research, on the complex H4R-mediated signals in various cell types & conditions
• Elucidation of the role of the H4R in models of allergy, inflammation, immune disorders, cancer & other conditions

Working Group 3:
Pharmacological properties of new selective H₄R ligands

• Design of selective H R ligands using traditional & modern tools for drug development
• Design of H4R ligands with additional properties (imaging, pharmacological profiling)
• Pharmacological & physicochemical evaluation of new promising drug candidates targeting the H4R (SAR, dose-response relationships, ADMET properties)

Working Group 4:
Therapeutic potential of new H₄R histaminergic compounds

• Set the standards for optimal translational research on H4R systems
• The H4R as a target for the treatment of inflammatory diseases, allergy & cancer:comparison with current therapeutic approaches
• Evaluation of current & potential clinical trials of H4R ligands
• Strategies & economic dimension of any novel therapeutic intervention

Contact info:Paul Chazot | Abdel Ennaceur
Webmaster: A Ennaceur
copyright: Histamine Research: Cost Action BM0806
updated: May 15th, 2012

Member of Histamine H4 - Cost Action BM0806: Memberlist in Googledocs

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Cory Teuscher has generated a panel or histamine receptor KO mice all on the B6/J background that
the community may be interested in using. He would be happy to provide them to anyone interested in a
collaborative fashion. Use of the mice with the H3- and H4- alleles will require clearance from J & J as
the constructs used their mice as the donors for the disrupted H3 and H4 receptors. To date they have been
extremely cooperative in this regard.
H1+H2-H3-H4- H1-H2+H3-H4- H1-H2-H3+H4- H1-H2-H3-H4+ H1-H2-H3+H4+ H1+H2+H3-H4- Etc. H1-H2-H3-H4-

Cory Teuscher       Cory Teuscher       Cory Teuscher       Cory Teuscher       Cory Teuscher